CORDIS Project

LightCure - Light for double specificity and efficacy without burden

LightCure·101080327·HORIZON

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View on CORDIS DOI grant

Funding data

Programme: Horizon Europe
Participants: 4
Start - End: 01/01/2024 — 31/12/2029
Status: SIGNED

Summary

This project aims to develop a targeted photodynamic therapy using a photosensitizer linked to exendin 4 to selectively damage hyperfunctioning beta cells in infants with congenital hyperinsulinism. The goal is to normalize blood glucose levels safely, reducing the severe health impacts and improving the quality of lif…

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Objective

Congenital hyperinsulinism (CHI) is a group of rare diseases of newborns and infants with functionally defective nonneoplastic beta-cells that cause hypoglycemia and severe morbidity through oversecretion of insulin. CHI is a major cause of hypoglycemic brain injury with intellectual disability, epilepsy and cerebral palsy.

As no registered causal therapy exists, management of CHI aims at increasing blood glucose levels causing severe side effects in all patients while life-threatening frequent…

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Coordinator

RADBOUDUMC

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM

Country: Netherlands, NIJMEGEN
Organization type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No

Network and participants(4 participants)

Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.

ERASMUS MC
Netherlands, Rotterdam
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany, Berlin
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant
HAW HAMBURG
Germany, Hamburg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant
MEDIZINISCHE UNIVERSITAET WIEN
Austria, Wien
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant

4 participants shown of 12

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CORDIS call / funding scheme

Programme: HORIZON
Call: HORIZON-HLTH-2022-DISEASE-06-two-stage
Sub call: HORIZON-HLTH-2022-DISEASE-06-two-stage
Funding scheme: HORIZON-RIA
Domain note: This block describes the CORDIS project call context. Live open opportunities are managed in the Funding & Tenders domain.

Fields of Science (EuroSciVoc)

Guests see up to 5 EuroSciVoc fields.

Medical and health sciencesBasic medicineNeurologyEpilepsy
Medical and health sciencesClinical medicineEndocrinologyDiabetes

Topic

Guests see up to 5 topics.

HORIZON-HLTH-2022-DISEASE-06-04-two-stage

Sector

Guests see up to 5 sectors.

Health & Biotech

Keywords

Guests see up to 5 keywords.

Minimally invasive therapy companion diagnostics positron emission tomography photodynamic therapy