CORDIS Project
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This project focuses on developing specific anti-HIV-1 drugs that target G-quadruplex structures in viral DNA and RNA. By utilizing reversible ligands and selective agents, the research aims to inhibit viral transcription and reverse transcription, potentially preventing HIV replication.
G-quadruplexes (G-4) are polymorphic nucleic acid structures identified in gene promoters where they act as transcription regulators. G-4s have been found in eukaryotic and prokaryotic organisms, while very little information is available on viruses.
The applicant research group has recently shown that HIV-1, which integrates into the human chromosomes and exploits cellular factors to activate transcription, takes advantage of G-4-mediated transcription regulation. G-4 disruption stimulates prom…
UNIVERSITA DEGLI STUDI DI PADOVA
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Italy, Pavia
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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