CORDIS Project
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This project explores the role of a newly identified cilium in meiosis, crucial for chromosomal pairing and fertility. By investigating its mechanical and regulatory functions, it aims to enhance understanding of reproductive biology and the implications of ciliary disorders.
A hallmark of meiosis is chromosomal pairing, which for decades has been a major focus in the field.
However, the nuclear events of meiosis occur in the cellular context of a differentiating gamete, and pairing depends on cytoplasmic counterparts, by mechanisms that are conserved from yeast to mammals.
These are essential for fertility, but how cytoplasmic counterparts of chromosomal pairing are regulated has remained enigmatic.
We uncovered a previously unrecognized cilium in meiosis – the zygo…
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