CORDIS Project
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This research focuses on the immune response triggered by left-handed nucleic acids during cellular stress. It aims to understand the activation mechanisms of the ZBP1 protein, which plays a crucial role in antiviral defense and cancer immunity.
Nucleic acids are potent inducers of an immune response.
Nucleic acids normally exist in a right-handed conformation.
However, during conditions of cellular stress, nucleic acids can also adopt an unusual, left-handed “Z-form”.
These Z-nucleic acids, including Z-RNA and Z-DNA, are sensed by two proteins:
ADAR1 and ZBP1.
While ADAR1 binding to Z-nucleic acids prevents immune responses, activation of ZBP1 results in the activation of an innate immune response.
It is clear, that ZBP1 has important…
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