CORDIS Project
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This project investigates how specific proteins recognize long DNA sequences, aiming to create predictive models for genome engineering and synthetic biology applications. By employing advanced single-molecule techniques, it seeks to understand the mechanisms of target recognition and improve the accuracy of genetic mo…
In the recent years a number of protein systems have been identified that recognize long (tens of base pairs) DNA sequences and allow flexible programmability of their target specificity.
This promoted an enormous range of applications in genome engineering and synthetic biology.
This project aims to decipher the mechanisms by which these proteins recognize their DNA targets in order to develop quantitative models/predictors for target recognition and to avoid off-target effects.To obtain detail…
UNIVERSITAET LEIPZIG
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