CORDIS Project
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This project focuses on developing engineered proteins that can target specific genes associated with various diseases, particularly cancer. By creating tools for gene repair and mutation, it aims to enhance research capabilities and potentially lead to therapeutic applications.
For the last ten years, protein engineering technologies have been developed to make zinc finger peptides to recognise a wide variety of user-defined DNA sequences.
This has enabled the construction of synthetic transcription factors that can upregulate or repress target genes at will.
More recently, synthetic zinc fingers have been linked to nucleases to direct double stranded breaks at desired loci within genomes.
These breaks increase the efficiency of homologous recombination so that, by pro…
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