CORDIS Project
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This project explores the role of Z-nucleic acids in activating immune responses through the ZBP1 sensor. It aims to understand the mechanisms of ZBP1 activation and its implications for antiviral and anticancer immunity, potentially leading to new therapeutic strategies.
Nucleic acids are potent activators of an immune response. Z-nucleic acids are poorly defined and thermodynamically unstable conformers of double-stranded RNA/DNA helices.
Recently, others and our group showed that Z-nucleic acids are recognised by the nucleic acid sensor ZBP1, thereby inducing an antiviral immune response.
Activation of ZBP1 has also been shown to induce anticancer immunity and it is becoming clear that chronic engagement of ZBP1 by endogenous Z-nucleic acids causes autoinflamm…
UNIVERSITEIT GENT
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