CORDIS Project
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This project focuses on understanding how blood stem cells maintain their ability to self-renew and differentiate into various blood cell types. By utilizing single-cell transcriptome sequencing in zebrafish, it aims to reconstruct the gene regulatory networks that govern blood cell formation.
Blood stem cells need to both perpetuate themselves (self-renew) and differentiate into all mature blood cells to maintain blood formation throughout life.
However, it is unclear how the underlying gene regulatory network maintains this population of self-renewing and differentiating stem cells, and how it accommodates the transition from a stem cell to a mature blood cell.
Our current knowledge of transcriptomes of various blood cell types has mainly been advanced by population-level analysis.…
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