CORDIS Project
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This project investigates the role of a specific enzyme from sperm in triggering calcium signals necessary for fertilization in mammals. By understanding how this enzyme interacts with egg proteins, the research aims to improve treatments for male infertility and enhance reproductive technologies.
Oocyte activation is the earliest step of embryonic development following mammalian fertilization and is triggered by a characteristic series of cytoplasmic Ca2+ transients, known as Ca2+ oscillations.
Over the last decade, growing evidence indicates that the physiological agent responsible for the generation of Ca2+ oscillations and subsequent oocyte activation is a sperm-specific isoform of phospholipase C (PLC), PLC-zeta (PLCz).
The sperm-borne PLCz stimulates Ca2+ oscillations in eggs after…
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