CORDIS Project
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This project aims to develop a zebrafish model to study the regulation of salt transport related to kidney function and hypertension. It focuses on understanding the mechanisms involved in sodium chloride transport and its physiological implications.
Kidney dysfunction is central to hypertension.
Mutations in the WNK/SPAK-OSR1 pathway cause human hypertension by modulating salt transport.
Yet, just when the physiological actions of these proteins appear clear, contradictory data raise questions about their effects, and leave investigators confused about physiological roles and mechanisms of disease.
Here, we propose to develop a novel zebrafish model system to permit us to study how NaCl transport is regulated.Our groups have used variety of…
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