CORDIS Project
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This project investigates the effects of chronic inflammation on hematopoietic stem cells, which are vital for blood cell production. By examining the role of interferon signaling in stem cell biology, it aims to improve understanding and treatment of hematological disorders.
Hematopoietic stem cells (HSCs), mostly quiescent cells in the bone marrow (BM), are essential throughout life because they are responsible for the continuous production of blood cells.
They are of major clinical significance in the context of transplantation for hematological malignancy and the treatment of genetic hematological diseases.
Despite major advances in our understanding of the biology of the blood system, understanding the progression of normal versus malignant hematopoiesis, clonal…
UNIVERSITA DEGLI STUDI DI PAVIA
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