CORDIS Project
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This project investigates the biogenesis of longer small non-coding RNAs derived from Y RNAs in mammalian cells. It aims to validate previous findings on their production mechanisms and enhance understanding of gene expression regulation through high-throughput mutagenesis.
Small non-coding RNAs play important roles in gene expression regulation.
Initially the attention was focused on the 21-24-nucleotide small RNAs such as microRNAs but later on deeper sequencing experiments using next generation sequencing revealed a slightly longer class of small RNAs that are 30-34 nucleotides long.
These longer small RNAs are often generated from known non-coding RNAs such as tRNA or snoRNA.
The biogenesis of these longer small RNAs seems to be diverse and is not well underst…
UNIVERSITY OF EAST ANGLIA
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