CORDIS Project
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This project focuses on developing efficient synthetic methods for creating biologically active compounds through a combination of cross-metathesis and rearrangement reactions. The goal is to establish new chiral catalysts and apply these methods in the synthesis of anti-HIV agents.
The aims of this research are to develop efficient synthetic methodology for one-pot catalytic cross-metathesis/tandem oxonium ylide formation– [2,3] sigmatropic rearrangement of unsaturated diazocarbonyl substrates, to establish a pool of useful chiral catalysts for this chemistry, and to apply this methodology in strategies for the enantioselective synthesis of selected biologically active natural product classes.
The objectives are:
Development and scope of one-pot cross-metathesis/tandem oxo…
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