CORDIS Project
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This project investigates the role of a specific protein, SP1, in regulating plastid development in plants. By manipulating SP1 expression in cereal crops, the aim is to enhance traits related to yield, such as stress resistance and delayed leaf senescence.
Recently, the host lab found that a novel ubiquitin E3 ligase, SP1, regulates the translocon of the outer chloroplast membrane (TOC), which is responsible for importing nucleus-encoded proteins into plastids. SP1 achieves this by promoting the degradation TOC components by the cytosolic 26S proteasome.
This is the first time the ubiquitin proteasome system (UPS) has been shown to directly regulate plastid development and function.
By increasing or decreasing SP1 levels in transgenic Arabidopsis…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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