CORDIS Project
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This project aims to enhance nuclear magnetic resonance (NMR) spectroscopy techniques to analyze large and complex protein assemblies, particularly those relevant to medical research. By developing innovative labelling methods and strategies, it seeks to simplify NMR spectra analysis and improve resolution for studying…
The cell is a collection of dynamic molecular machines. NMR spectroscopy is the method of choice to observe, at atomic resolution, complex conformational changes, transient interactions and dynamics of proteins.
Introduction of methyl specific labelling technology has enabled solution NMR studies of protein assemblies of several hundred kDa.
However, this strategy is mostly restricted to symmetrical and thermostable protein assemblies, precluding applications to large medically relevant biologic…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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