CORDIS Project
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The project aims to uncover how mitotic chromosomes are formed from interphase nuclei using innovative experimental designs and high-resolution techniques. By synchronizing cell lines and employing advanced imaging methods, it will map chromatin distribution and analyze the mechanisms involved in chromosome formation.
The remarkable morphological transformation that cells undergo during mitosis has been studied for >140 years, but how mitotic chromosomes are built from interphase nuclei remains unknown and challenging to study.
We propose to uncover the mechanisms for this process at high-resolution in cells and in vitro, a task that requires coordinated implementation of innovative experimental designs in several disciplines.
We will engineer mutant and hybrid cell lines that enter mitosis with minute-by-min…
UNIVERSITAT ZURICH
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