CORDIS Project
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This research project explores how DNA damage affects chromatin structure, particularly in the context of the inactive X chromosome in female mammals. By using CRISPR technology, it aims to understand the relationship between DNA repair mechanisms and chromatin states, which could have implications for gene expression…
The DNA damage response takes place on a chromatin substrate and triggers profound chromatin alterations.
Chromatin states vary substantially between genomic regions, driving distinct gene expression profiles and also different DNA damage repair responses.
One striking example is the heterochromatinization of an entire chromosome, the inactive X chromosome in female mammals, that is silenced during embryonic development by facultative heterochromatin formation.
How the facultative heterochromati…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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France, PARIS
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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