CORDIS Project
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This project explores the role of xeno-autoantibodies against dietary sugars in cancer. It aims to understand how these antibodies can both promote and inhibit tumor growth, using advanced techniques to study their effects in a mouse model.
‘xeno-autoantibodies’ recognize a dietary immunogenic non-self sugar that is metabolized by cells as self and presented on the cell surface. N-acetylneuraminic acid (Neu5Ac) and its hydroxylated form, N-glycolylneuraminic acid (Neu5Gc) are the two major Sia forms in most mammals.
Humans are deficient in the enzyme CMP-Neu5Ac hydroxylase (CMAH) that can synthesize Neu5Gc, however dietary Neu5Gc accumulates in epithelial tumors and become immunogenic.
Our previous research recognized dual and opp…
TEL AVIV UNIVERSITY
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