CORDIS Project
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This project investigates the mechanisms behind the lethality associated with having only one X chromosome in certain species. By using fruit flies as a model, it aims to understand how X chromosome dosage affects development and the physiological consequences of its imbalance.
Sex chromosomes are critical for controlling the phenotypic differences between males and females.
However, they also create an imbalance in the gene products of sex-linked genes, with males having only one copy and females having two copies.
To counteract this imbalance, many species evolved a chromosome-wide mechanism known as dosage compensation, which helps equalise gene expression between the sexes.
This process is vital, as failed dosage compensation can lead to sex-specific disorders and…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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