CORDIS Project
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This project investigates the early stages of X chromosome inactivation in female mammals, focusing on the differences in chromatin structure between paternal and maternal X chromosomes during embryonic development. By analyzing chromatin modifications and organization, it aims to uncover the molecular mechanisms of ep…
In mammals, one of the two X chromosomes is inactivated in females to enable dosage compensation for X-linked gene products.
In mice, the first changes associated with X-inactivation occur during early pre-implantation embryogenesis.
At the morula-blastocyst transition, paternal and maternal X chromosomes are differentially reprogrammed in the three cell lineages constitutive of the late blastocyst.
In order to characterise the factors and epigenetic marks involved in this reprogramming process,…
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