CORDIS Project
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This project investigates the role of the X chromosome in male fertility and sex differentiation in mammals. By using CRISPR technology, it aims to identify critical genes on both X and Y chromosomes that influence germ line development and contribute to male infertility.
Male and female mammals differ in their sex chromosome complement: males have one X chromosome and one Y chromosome (XY), while females have two X chromosomes (XX).
Decades of research have demonstrated that the Y chromosome is crucial for male fertility, regulating both sex differentiation and spermatogenesis.
However, the role of the X chromosome in these critical stages of germ line development remains poorly understood.In this proposal, we will explore the functions of the X chromosome in th…
THE FRANCIS CRICK INSTITUTE LIMITED
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