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The X-CITE project investigates how certain genes on the X chromosome influence T cell responses, particularly in the context of cancer immunotherapy. It aims to uncover the molecular mechanisms behind sex differences in immune function.
Sex differences play a significant role in immune function, with women generally mounting stronger immune responses than men. A key factor behind these differences is the X chromosome, which contains many genes that are important for immune function.
In females, who have two X chromosomes, one of the X chromosomes is usually inactivated in each cell to prevent an overdose of X-linked gene expression.
This process is known as X-chromosome inactivation (XCI).
However, some genes can escape this in…
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