CORDIS Project
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This project studies the role of the Wt1 gene in heart development, particularly its impact on the formation of coronary blood vessels and heart cells. By investigating gene deletion effects, it aims to uncover mechanisms that could aid heart regeneration.
The epicardium is a mesothelial tissue that plays a crucial role during heart development, by contributing to the formation of cardiovascular precursor cells and by producing growth factors important for heart formation.
Wt1 gene encodes a zinc finger protein, which plays a critical role in normal development of several organs such as kidney, gonads, spleen and heart.
During heart formation, Wt1 is mainly expressed in the epicardium and epicardial derived cells.
Deletion of Wt1 gene in an epic…
UNIVERSITAT DE BARCELONA
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