CORDIS Project
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This project aims to enhance the production of biodiesel by studying wax ester synthases and their structure-function relationships. By engineering these enzymes to favor ethanol, the research seeks to improve microbial systems for biodiesel production and create tailor-made chemicals.
The recently discovered wax ester synthases (WS/DGATs) have demonstrated potential to catalyze production of biodiesel (microdiesel) by microbial systems.
However, one inherent feature of WS/DGATs, their preference of long chain fatty alcohols as co-substrate, prevents efficient use of WS/DGATs for production of biodiesel.
Future structure-guided protein engineering studies to increase the selectivity of WS/DGATs towards ethanol should facilitate de novo biodiesel production by more effective us…
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