CORDIS Project
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This project explores the use of Wolbachia, a symbiotic bacterium, to enhance disease control in insects. It aims to develop advanced gene manipulation techniques to study Wolbachia's role in antiviral resistance and symbiosis, ultimately improving strategies for disease prevention and treatment.
Wolbachia is a widespread, intracellular symbiont of arthropods and filarial nematodes, inducing reproductive distortions and antiviral protection in insects.
Wolbachia is currently being deployed in disease vector control programs and is also a target in the treatment of lymphatic filariasis.
Despite its prevalence, fascinating phenotypes, and applied importance, Wolbachia biology remains poorly explored, as it cannot be cultured or genetically manipulated.
To date, antisense RNA and a transfec…
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