CORDIS Project
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This project investigates the role of long intergenic non-coding RNAs in the Wnt signaling pathway, which is crucial for stem cell function and colorectal cancer. It aims to identify these RNAs, their interacting protein factors, and their contributions to gene regulation in intestinal health and disease.
The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation and proliferation in the adult, self-renewing intestinal epithelium.
Wnt signaling activates gene expression through the induced formation of complexes between DNA-binding TCF factors and the transcriptional co-activator β-catenin.
Constitutive, aberrant transcriptional activity of the TCF4/β-catenin complex, caused by mutations in APC, AXIN or β-catenin, is the primary transforming factor in colorectal canc…
BIOMEDICALSCIENCES RESEARCH CENTER ALEXANDER FLEMING
EREVNITIKO KENTRO VIOIATRIKON EPISTIMON ALEXANDROS FLEMINGK
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