CORDIS Project
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This project investigates the trafficking and secretion of Wingless, a key signaling protein in Drosophila, focusing on its journey from the endoplasmic reticulum to target cells. It explores the role of exosomes and lipid modifications in Wingless diffusion and retention, with implications for understanding Wnt signal…
Wnts are signaling proteins that act both at short and long range in developing tissues.
Several proteins, such as Wntless, are specifically devoted to Wnt secretion, indicating that Wnts may follow a distinct secretory route.
Moreover, Wnts carry two lipid modifications, which are likely to interfere with diffusion in the extracellular space.
Much of our work will focus on the trafficking of Wingless (the main Drosophila Wnt), which forms a concentration gradient in wing imaginal discs.
To char…
THE FRANCIS CRICK INSTITUTE LIMITED
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United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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