CORDIS Project
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This project investigates how early neural activity influences the development of brain circuits, particularly in the visual system. By silencing spontaneous activity in neurons, it aims to understand the molecular interactions that shape initial neuronal connections and how these connections adapt to sensory experienc…
A fundamental feature of the developing neural circuits is their ability to change in response to sensorial experience.
This phenomenon has been particularly observed during the generation of cortical maps, where altering the pattern of sensory experience changes the spatial organization of sensory representations.
The mechanisms underlying this form of plasticity include synaptic modification such as long-term potentiation and long-term depression, classically referred to as Hebbian-based rules…
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