CORDIS Project
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This project investigates the role of microRNAs in gene expression regulation and cell reprogramming. It aims to understand how microRNAs interact with transcription factors to influence cell identity and differentiation, particularly in converting somatic cells into induced pluripotent stem cells.
miRNAs are small RNAs that guide the RNA-induced silencing complex tomRNA targets, destabilizing them and inhibiting theirtranslation.
Much has been learned about their involvement in organismdevelopment and function, yet some striking puzzles remain.
On the onehand it has been shown that miRNAs are essential for development, andthe preferential targeting of transcription factors (TFs) by miRNAssuggests that miRNAs and TFs ""coordinate"" to regulate geneexpression.
Furthermore, studies in the pa…
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