CORDIS Project
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This project investigates the regulation of toxin production in Clostridium botulinum, focusing on the mechanisms that control the synthesis of botulinum neurotoxin. By studying single-cell behavior and genetic factors, it aims to inform new strategies for antitoxins and vaccines.
Bacterial toxins cause devastating diseases in humans and animals, ranging from necrotic enteritis to gas gangrene and tetraplegia.
While toxin synthesis probably endows these bacteria with a selective advantage in their natural habitats, toxigenesis is likely to represent a fitness cost.
It is thus plausible that mild environments encourage bacteria to give up toxin production, or reduce the number of toxigenic cells in populations.
The cellular strategies bacteria use to silence toxin producti…
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