CORDIS Project
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This project aims to identify imprinted genetic regions in humans by analyzing methylation patterns in specific tissues with paternal or maternal contributions. It also investigates the role of these patterns in developmental disorders, particularly through studies of genetically identical twins with differing traits.
First, I propose to identify all imprinted loci in humans.
I will perform a whole-genome screen using high-density oligonucleotide microarrays coupled with immunoprecipitation of methylated DNA to compare the methylation patterns in rare uniparental tissues.
I have obtained samples from complete hydatidiform moles, which have an exclusively paternal genetic contribution, and ovarian teratomas, which have an exclusively maternal genetic contribution.
I demonstrate that the study of genomic methyl…
UNIVERSITE DE GENEVE
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