CORDIS Project
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This project investigates the role of estrogen receptors in the liver and their influence on energy metabolism during reproductive cycles. It aims to uncover the molecular pathways involved and their implications for metabolic disorders in women, potentially leading to new therapeutic approaches.
In mammals, the liver is the peripheral integrator of nutrient availability and energetic needs of the entire organism.
We recently demonstrated that dietary amino acids (AA) activate liver Estrogen Receptors (ER) and that, in case of food scarcity, the lowered circulating AA decrease liver ER activity and reduce IGF-1 synthesis with the consequent blockage of the estrous cycle.Here, we hypothesize that in females liver ERa is also a sensor of the endogenous signalling induced by transitions amo…
UNIVERSITA DEGLI STUDI DI MILANO
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