CORDIS Project
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This study focuses on the role of the BAP1 protein in clear-cell renal cell carcinoma, particularly its impact on metastasis. The project aims to uncover the molecular mechanisms behind BAP1 loss and explore potential therapeutic strategies.
Kidney cancer is among the ten most prevalent cancers arising in Western countries, with clear-cell renal cell carcinoma (ccRCC) being the most frequent subtype (75%).
About 30% of ccRCC patients present with metastatic disease at diagnosis, and another 30% will develop metastases after surgery.
When metastatic, ccRCC remains largely incurable. I recently discovered that the tumor suppressor BAP1 (BRCA1-associated protein 1) is inactivated in 15% of ccRCCs (Peña-Llopis et al.
Nat.
Genet. 2012).…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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