CORDIS Project
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This research project aims to identify cellular RNA-binding proteins that play key roles in RNA virus infections. Using a novel method called viral RNA interactome capture, the project will explore how these proteins interact with viral RNA and their potential as targets for antiviral therapies.
RNA is a central molecule for RNA virRNA is a central molecule for RNA virus infection.
However, viral genomes encode very few proteins that are able to interact with viral RNA.
Hence, viruses co-opt cellular RNA-binding proteins (RBPs) to support infection.
The host cell also employs RBPs to combat viruses through the recognition of unusual signatures present viral RNAs.
Despite these critical roles, the complement of cellular RBPs involved in infection remains largely unknown.
This research pr…
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