CORDIS Project
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This project explores the mechanisms of voltage sensing in proteins, focusing on the voltage-sensor domain. It aims to understand the variability in voltage-sensing properties through computational methods, which could illuminate the effects of mutations related to channelopathies.
Voltage sensing is a crucial property for a variety of proteins involved in many physiological functions (selective ion transport through membranes, enzymatic catalysis…).
All these proteins achieve voltage sensing through the action of a 4 alpha-helix bundle module called the voltage-sensor domain (VSD).
This transmembrane module achieves its function thanks to specific features, such as the presence of a large number of conserved charged or hydrophobic residues isolating the intracellular doma…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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