CORDIS Project
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This research focuses on understanding how cells regulate their volume in response to various physiological conditions. It identifies key ion channels that play a role in this process, which could have implications for cell biology and medical research.
Cells must regulate their volume in response to changes in osmolarity and during cell division, migration, apoptosis, and transepithelial transport.
Regulated membrane transport of ions and metabolites creates osmotic gradients that secondarily drive water across the membrane.
Organic ‘osmolytes’ such as glutamate also serve in extracellular signalling and volume-regulatory ion transporters are often used for other purposes, putting volume regulation into the context of diverse organismal functi…
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