CORDIS Project
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This project investigates how the Volume-Regulated Anion Channel (VRAC) influences liver function by regulating hepatocyte volume and metabolism. By utilizing genetically modified mouse models, the research aims to clarify the mechanisms of volume sensing and its impact on liver physiology.
A fundamental property of animal cells is the ability to maintain their volume constant to face changes in osmolarity and during division, migration and transepithelial transport.
There is emerging evidence that cell swelling also initiates signaling cascades that regulate metabolism, particularly in hepatocytes.
However, the basic mechanisms responsible for sensing volume changes and initiating volume-regulated signaling cascades in the liver remain largely unclear.
As major player in cell volu…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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