CORDIS Project
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This project investigates the role of Piwi-interacting RNA in the antiviral immune response of mosquitoes, particularly in relation to arboviruses. It aims to characterize the biogenesis and function of novel classes of piRNAs and their interactions with viruses.
BACKGROUND:
Mosquitoes and other blood-feeding arthropods transmit important human and animal viruses (arthropod-borne viruses, arboviruses).
With the increasing global threat of arboviruses, it is essential to understand the virus-vector interactions that determine virus transmission.
The mosquito antiviral immune response is a key determinant of virus replication and transmission.
We recently showed that arboviruses are targeted by a poorly-understood RNA silencing pathway in the major vector…
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