CORDIS Project
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VIVA-ELISA is developing a rapid diagnostic test for early detection of sepsis by measuring NLRP3 inflammasome activation in patients. This test aims to improve prognosis and reduce mortality rates through timely intervention and personalized treatment strategies.
Sepsis causes almost 20% of global annual deaths.
It involves a dysregulated systemic inflammatory response driven by proinflammatory cytokines.
If untreated, it progresses to organ dysfunction, low blood pressure, and septic shock.
Current diagnosis methods have low predictability, delays in diagnosis, lack of sensitivity, and an inability to predict the course of the patients deterioration: there is thus a need for a rapid, accurate, affordable and early identification of the mortality risk.VI…
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