CORDIS Project
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This research explores how vitamin A signaling affects the maintenance and differentiation of hematopoietic stem cells. It aims to uncover the mechanisms regulating stem cell quiescence, which is crucial for developing effective therapies for blood-related diseases.
Quiescence preserves the self-renewal capacity and the long-term function of hematopoietic stem cells (HSCs).
The regulators of this dormant state include intrinsic pathways and soluble components in the bone marrow niche.
Dysregulation of this process is poorly defined and might cause aberrant hematopoiesis.
In my previous work, we defined the molecular landscape of HSCs by applying state of the art DNA-methylome, RNA-seq and proteome analyses, and found vitamin A/retinoic acid (RA)-induced sig…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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