CORDIS Project
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This project investigates how Shigella bacteria invade human colon cells by examining the interaction between bacterial proteins and host cell membranes. Using advanced imaging techniques, it aims to reveal the molecular and spatial dynamics of this invasion process, enhancing our understanding of host-pathogen interac…
A key step of Shigella infection is the invasion of epithelial cells of the human colon.
The contact with host cells triggers the injection of bacterial effector proteins into the host cells via the type III secretion system (T3SS).
The effectors induce massive cytoskeletal remodelling (actin foci).
This drives localized membrane ruffling and lamellipodial extensions that envelop and internalize the bacteria.
We will investigate at molecular resolution and in three dimensions (3D) how the succes…
INSTITUT PASTEUR
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