CORDIS Project
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This project explores how cells manage misfolded proteins, particularly in aging and disease. It employs innovative techniques to visualize cellular responses to unfolded proteins, aiming to enhance understanding of protein quality control and its implications for diagnostics and therapeutics.
The capacity of the cell to maintain protein quality and function diminishes upon aging and disease.
Genetic mutations may result in protein malfunction or structural defects due to an alternation of an essential amino acid.
The cell has evolved many mechanisms to handle misfolded proteins; some proteins are refolded by molecular chaperones while others are targeted for degradation by the ubiquitin proteasome system and yet others are sequestered in deposits at a specific cellular location.
How…
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