CORDIS Project
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This project focuses on enhancing RNA interference techniques to develop advanced lentiviral short hairpin RNA library screens. It aims to identify host factors crucial for human herpesvirus infections and improve antiviral therapy strategies by targeting specific host genes involved in viral replication.
RNA interference (RNAi) is a process of double-stranded RNA-dependent post-transcriptional gene silencing.
It has become one of the most powerful and widely used strategies for genetic analysis based on the highly specific and efficient silencing of target genes. RNAi library screens have gained much attention from virologists resulting in the publication of several whole-genome short interfering RNA (siRNA) screens that identified numerous new host genes impacting RNA-virus replication.
Althoug…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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