CORDIS Project
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This project investigates the role of FIKK kinases in the cytoadhesion and rigidity of Plasmodium falciparum-infected red blood cells. By understanding how these kinases influence malaria pathology, the research aims to uncover mechanisms that could lead to better treatments for severe malaria cases.
The most severe form of malaria in humans is caused by Plasmodium falciparum.
Cytoadhesion of infected red blood cells (iRBCs) to host endothelium and iRBC rigidification are the major contributors to pathology.
Cytoadhesion is mediated by transport of a protein called PfEMP1 onto the surface of the iRBC.
It prevents clearance of iRBCs in the spleen and promotes parasite survival, but can cause the obstruction of blood vessels leading to pathology.
Thus, the parasite has to strike a fine balance…
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Portugal, Lisboa
Type: Research institute
Activity type: Research Organisations
SME: No
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