CORDIS Project
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This project aims to investigate the infection mechanisms of the Dengue virus using tissue-engineered human skin. By combining advanced cell culture techniques and virology, it seeks to understand the interactions between the virus and human sensory neurons.
Although inflammatory and neurological diseases caused by arthropod-borne viruses progress worldwide, biomedical advances are slow, still leaving patients to palliative care.
New approaches to arboviral pathogenesis are needed to overcome the limitations imposed by inappropriate experimental systems.
Here I propose to use tissue-engineered human skin, comprising immune cells and sensory nerve cells, and naturally-infected mosquitos to investigate infection and cell responses to the Dengue arbovi…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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