CORDIS Project
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This project investigates the Epstein–Barr virus (EBV) and its role in certain cancers, focusing on the BILF1 protein as a potential therapeutic target. By understanding how BILF1 influences cancer cell behavior, the project aims to pave the way for new antiviral drugs to treat EBV-related malignancies.
The Epstein–Barr virus (EBV) is widespread in all human communities.
While most people carry EBV as a life-long asymptomatic infection, in some people, EBV contributes to malignant transformation and is responsible for ~200,000 new cancer cases/year.
Small molecule inhibitors targeting viral proteins could be an effective option to treat people with EBV-associated cancers.
However, no such drugs exists which in part reflects the limited repertoire of targetable virus proteins present in EBV-driv…
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