CORDIS Project
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This project investigates the endosomal sorting complex required for transport (ESCRT) and its role in membrane budding and vesicle formation. It aims to develop theoretical models to understand the energy dynamics involved in these processes.
The endosomal sorting complex required for transport (ESCRT) is a multi-protein complex, which facilitates many processes in biological cells.
In particular, it is central to trafficking of membrane proteins and budding of certain enveloped viruses such as HIV.
Recent experimental data show that certain ESCRT proteins that associate with lipid membranes assemble into polymer-like structures.
These protein aggregates, or polymers, act to buckle the membrane locally and, in this way, drive the for…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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