CORDIS Project
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This project focuses on the therapeutic potential of nuclear calcium signaling in treating neurological disorders. It aims to develop novel drug targets and validate a lead compound for stroke therapy, enhancing early drug discovery processes.
Several forms of neuroadaptation are controlled by transient increases in the nuclear calcium concentration.
Nuclear calcium regulates expression of crucial genes and alterations of this signaling network likely underlie many neurological disorders.
Our work led us to design two innovative strategies exploiting the therapeutic potential of nuclear calcium signaling: 1-developing direct nuclear calcium signaling activators/inhibitors (NCSA/I) and 2-manipulating expression and/or function of nucle…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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