CORDIS Project
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This project focuses on developing a novel immunotherapy that allows for the safe engineering of T cells and B cells using adeno-associated vectors. It aims to improve cancer treatment and autoimmune disease management by targeting specific genes within lymphocytes.
T cell engineering has shown clinical success mainly in haematological cancers, but scaling up is challenging due to reliance on ex vivo manipulations.
In addition, B cell engineering has not shown therapeutic efficacy to date.
Here, we propose a novel immunotherapy approach, allowing safe and efficient engineering of B cells and T cells, both ex vivo and in vivo.
We will use adeno associated vectors (AAV) to integrate chimeric antigen receptor (CAR) or T cell receptor (TCR) genes into loci codi…
TEL AVIV UNIVERSITY
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