CORDIS Project
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The Vascular-Rhythm project investigates how endothelial cells adapt to daily environmental changes, focusing on their responses to circadian rhythms. By analyzing these adaptations in different organs, the project aims to uncover new insights into vascular health and aging.
A quiescent, resilient layer of blood vessel-lining endothelial cells (ECs) is vital for maintaining organ function and enabling healthy aging.
Much has been learnt in recent years about the mechanisms controlling the resilient EC phenotype.
In turn, little is known if and how mechanisms of vascular resilience are affected by environmental rhythmic stimuli (extrinsic (e.g., light-dark, feeding-fasting) or intrinsic (e.g., blood pressure, hematopoiesis)).
Performing day/night analyses of mouse li…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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